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Metoclopramide is a prescription medication used to treat gastroesophageal reflux disease (GERD) when certain other treatments do not work and to relieve symptoms of slow stomach emptying in people with diabetes.

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Treatment of Patients with Diabetic Gastroparesis: In patients with diabetes, damage to vagal nerves in the stomach due to years of hyperglycemia can interfere with muscle function, resulting in delayed emptying of the stomach, nausea, vomiting, a sense of abdominal fullness or distention, and heartburn (diabetic gastroparesis).

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In general, patients usually do not exceed 12 weeks of medication to reduce the chance of developing tardive dyskinesia.

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Neonatal susceptibility to methemoglobinemia is increased due to prolonged clearance (may cause excessive serum concentrations) in combination with decreased neonatal levels of cytochrome-b 5 reductase.

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In the pediatric setting, treatment is usually not indicated in the absence of mucosal bleeding regardless of platelet count.

For example, 7 defined daily doses would be a total of 21 metoclopramide tablets of 10 mg each taken either as 30 mg per day for 7 days or as a total of 210 mg taken over the course of the first trimester.

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