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In a 12-month clinical trial, patients treated with a daily 400 mg dose of Gleevec (imatinib mesylate) were nine times more likely to achieve normal blood cell counts compared with those treated with conventional therapy.

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Side effects of nilotinib seem to be mild, but can include fluid buildup, lowered blood cell counts, nausea, diarrhea, and some lab test abnormalities.

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Advise patients to tell their doctor if they are taking or plan to take iron supplements.

Gleevec) was discovered in 1992 and is regarded as first generation drug since it is the first Bcr-Abl tyrosine kinase inhibitor to be used in the treatment of CML.

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It is probably advisable to start with lower dosages in patients with impaired renal function, due to slower elimination of the drug and metabolites and a greater cumulative effect.

With these factors, quarter-two core operating income could be a high single digit decline in constant currencies versus prior year.

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Even if Gleevec does protect the beta cells, study participants may still need to take insulin injections and actively manage their diabetes.

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